PKRRATING - AN OVERVIEW

autophosphorylation at T466 is not feasible in this geometry along with the docking web-site on helix αG for that substrate eIF2α is blocked. However, similar interfaces using the αEF and αG helices are actually documented for trans-autophosphorylation complexes of PAK159 and PknB60. The mechanistic relevance of activation loop exchange was pr